We’ve released a new version of IgBLAST, v1.12. This new version increases the allowed distance between V gene end and J gene start positions (from 90 bp to 150 bp) as well as between V gene end and D gene start positions (from 55 to 120 bp) to accommodate extremely long VDJ junctions found in some antibodies.
IgBLAST 1.12 uses the 1-based sequence coordinate system that reflects the change in the new AIRR Rearrangement Schema. Also, it includes fixes for minor bugs found in previous versions.
The new executables are available on the NCBI FTP site.
For more information, please read:
- Release notes
- IgBLAST manual on GitHub
- IgBLAST: an immunoglobulin variable domain sequence analysis tool. Nucleic Acids Research
IgBLAST facilitates the analysis of immunoglobulin and T cell receptor variable domain sequences.
Complementarity-determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively, where these molecules bind to their specific antigen. A set of CDRs constitutes a paratope.
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. … The part of an antibody that binds to the epitope is called a paratope.
Bring it on