IgBLAST is a popular NCBI package for classifying and analyzing immunoglobulin (IG) and T cell receptor (TCR) variable domain sequences. We’ve released a new version (1.14.0) of IgBLAST with three new improvements / bug fixes:
- Adaptive Immune Receptor Repertoire (AIRR) format is more consistent with AIRR specs including changing undefined type (NON, N/A) to empty string, not appending “reversed” to sequence identifier when the query is in reversed orientation, and using standard locus names such as IGH, TRB instead of traditional VH, VB etc.
- The logic for showing CDR3 end of TCR sequences is improved.
- The sequence identifier is restored in the case of no results in AIRR rearrangement format.
IgBLAST 1.14 is available for download from the BLAST FTP area. See the the new manual on GitHub for information about setting up and running IgBLAST.