IgBLAST is a popular NCBI package for classifying and analyzing immunoglobulin (IG) and T cell receptor (TCR) variable domain sequences. We’ve released a new version (1.15.0) of IgBLAST with four new improvements / bug fixes:
- Support for the new framework region 4 (FWR4) annotation feature in the standard alignment formats and AIRR format.
- Renamed the previous “-penalty” parameter to -V_penalty to be consistent with other IgBLAST penalty options.
- Restored constant internal BLAST search parameters for domain annotation (i.e., FWR/CDR) so that this process is not influenced by user-provided parameters.
- Corrected FWR/CDR annotations for certain mouse VK and rat VH germline genes.