A new way to view and download related genes
As previously announced, HomoloGene now automatically redirects to the NCBI Datasets Gene page giving you easy access to up-to-date sequence and homology data. The NCBI Datasets Gene Table provides a link to NCBI Orthologs with expanded gene and protein information and links to tools. NCBI Orthologs includes more genes and sequences for a growing range of taxa. See an example below. Legacy HomoloGene data remains available on the FTP site.
Figure 1: Access to NCBI Orthologs through the NCBI Datasets Gene page (A) where you can search with an organism, gene symbol, or gene ID. B) NCBI Datasets Gene table results for human protein coding genes with links to the Ortholog set for each gene in the table. C) NCBI Orthologs for APOE. You can access additional related genes through the “Genes similar to APOE” link at the top of the APOE Orthologs page.
Need ortholog data on the command line?
Use the NCBI Datasets command line tool to download an ortholog data package.
Learn more
For more information about NCBI Datasets and for step-by-step instructions on how to use it, see our help documentation.
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NCBI Datasets supports the NIH Comparative Genomics Resource (CGR). CGR facilitates reliable comparative genomics analyses for all eukaryotic organisms through an NCBI Toolkit and community collaboration.
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We want to hear from you!
Try out the new experience and let us know what you think. If you have questions or would like to provide feedback, please reach out to us at info@ncbi.nlm.nih.gov.
Multiple pairwise protein alignment used to be very simple on Homologene. Now it seems I can’t access it without doing a manual protein blast. Can you tell me how to get this highly useful function back?
Hi! Thank you for your feedback and question. Please write to our help desk so we can assist you: https://support.nlm.nih.gov/support/create-case/