RefSeq Release 98 is public


RefSeq release 98 is accessible online, via FTP and through NCBI’s Entrez programming utilities, E-utilities.

This full release incorporates genomic, transcript, and protein data available as of January 6, 2020, and contains 223,560,051 records, including 161,133,441 proteins, 29,134,515 RNAs, and sequences from 98,406 organisms.

The release is provided in several directories as a complete dataset and as divided by logical groupings.

Read on for several important announcements.

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RefSeq Release 97 is public


RefSeq release 97 is accessible online, via FTP and through NCBI’s Entrez programming utilities, E-utilities.

This full release incorporates genomic, transcript, and protein data available, as of November 4, 2019 and contains 219,407,891 records, including 157,639,958 proteins, 28,730,283 RNAs, and sequences from 97,407 organisms.

The release is provided in several directories as a complete dataset and also as divided by logical groupings.

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August-October 2019 RefSeq annotations: mouse, firefly and more


mouse with dark brown fur, eating

Recently, the NCBI Eukaryotic Genome Annotation Pipeline has released new annotations in RefSeq for the following organisms:

  • Aedes albopictus (Asian tiger mosquito)
  • Aquila chrysaetos chrysaetos (golden eagle)
  • Archocentrus centrarchus (flier cichlid)
  • Calypte anna (Anna’s hummingbird)
  • Camarhynchus parvulus (bird)
  • Camelus dromedarius (Arabian camel)
  • Cannabis sativa (hemp)
  • Chanos chanos (milkfish)

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RefSeq Release 96: complete re-annotation of mouse genome and new human annotation


You can now access RefSeq release 96  online, from the FTP  site, and through NCBI’s Entrez programming utilities (E-utilities).

This full release incorporates genomic, transcript, and protein data available, as of September 9, 2019 and contains 213,863,503 records, including 152,910,397 proteins, 28,017,380 RNAs, and sequences from 94,946 organisms.

The release is provided  as a complete dataset and also in several directories divided by logical groupings.

Special announcements:

1. New Mus musculus (house mouse) Annotation Release 108

The latest annotation run for Mus musculus, 108, is a complete re-annotation of the mouse GRCm38.p6 assembly that incorporates ongoing curation work and new computed models based on extensive long-read transcriptome data.
See the annotation report for  details.  You can access these  annotation products through the sequence databases and on the FTP site.

2. Updated Homo sapiens Annotation Release 109.20190905

Annotation Release 109.20190905 is an update of NCBI Homo sapiens Annotation Release 109. The annotation report has details. You can access the annotation products from the sequence databases or download the data from the FTP site. We will continue to update the human genome annotation frequently so that we can
incorporate ongoing curation work including the MANE project and other curation activities. See our post on the increased frequency of annotation for more information on the new schedule.

3. dbSNP Human Build 153

The short variations (SNPs) annotated on human RefSeq transcripts and RefSeqGene records now incorporate data from dbSNP build 153.

Evidence for naming the protein now on non-redundant refseq records (WP_ accessions)


We are now showing the curated evidence used for assigning names and, if possible, gene symbols, publications, and Enzyme Commission numbers on nearly 70% (83 million) microbial RefSeq proteins. This evidence includes a hierarchical collection of curated Hidden Markov Model (HMM)-based and BLAST-based protein families, and conserved domain architectures.

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RefSeq release 95: naming evidence added to all relevant WP proteins


RefSeq release 95 is accessible online, via FTP and through NCBI’s Entrez programming utilities, E-utilities.

This full release incorporates genomic, transcript, and protein data available, as of July 8, 2019 and contains 206,416,381 records, including 146,381,777 proteins, 27,212,750 RNAs, and sequences from 93,618 organisms.

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RefSeq release 94 with MANE and RefSeq Select markup, protein name evidence, and improved [Candida] auris assembly


RefSeq release 94 is now available through NCBI web services, FTP and through NCBI’s Entrez programming utilities, E-utilities.

This full release incorporates genomic, transcript, and protein data available, as of May 13, 2019 and contains 200,311,267 records, including 141,839,334 proteins, 26,534,602 RNAs, and sequences from 91,873 organisms. The release is provided in several directories as a complete dataset and also as divided by logical groupings.

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